The importance of utilizing unmanned systems, and more specifically Unmanned Aerial Vehicles (UAVs), in a wide variety of civilian and military missions has been recognized by many private and governmental aerospace & defense contractors around the globe. Seizing on this technological trend, GlobVision has developed state-of-the-art autonomous fault-tolerant control systems that improve the security, reliability and performance of UAVs while they are performing their mission. GlobVision’s technology has been applied and tested for autonomous fault diagnosis and reconfigurable flight control of a fixed-wing UAV.